Sr. Scientist/Principal Scientist, Formulation- LNP

Company: 76Bio, Inc.

Location: Boston, MA

76Bio is seeking a highly motivated and talented formulation scientist to help build a delivery platform to realize the potential of our TPD platform. The individual will work closely with the medicinal chemistry team to design novel lipid nanoparticles for efficient delivery to tumors. They will help develop and drive the formulation strategy. They will be accountable for mentoring the rest of the formulation discovery team in designing and executing experiments to optimize processes and compositions, aimed at improving the biological activity and manufacturability of the delivery vehicles. They will be an integral member of a cross functional team, providing interpretation of data and contributing to the strategic direction of the project.

Key Responsibilities:

· Work with the medicinal chemistry team to design and execute on a formulation strategy for testing new lipid components

· Design and develop optimal formulation processes and compositions to improve LNP delivery to tumor

· Manufacture and perform bio-physical characterization of LNPs for in vitro and in vivo experiments

· Ensure efficiency of workflows and integration of high-throughput methods where feasible

· Explore alternative characterization methods to aid in building our structure function relationships

· Collaborate with biology colleagues on designing assays to better understand LNP biology

· Collaborate with pharmacology colleagues in testing novel LNPs in vivo and interpretation of the results

· Serve as subject matter expert in collaborations with technology partners and CDMOs ensuring quality and consistency of results

· Present formulation strategy and results to internal and external stakeholders, including executive committee and SAB

· Coordinate with colleagues on sample preparation and shipping LNP samples for testing at CROs

· Capturing and recording experimental details and analyses in a laboratory notebook