Description

We are seeking an experienced Lipid Nanoparticle (LNP) Formulation Scientist to drive the design, execution, and analysis of Design of Experiments (DOE) to establish cutting-edge next-generation LNP platforms focusing on different disease areas. This role will play a critical part in developing, optimizing, and characterizing LNP systems for nucleic acid delivery in a fast-paced, collaborative research environment.

Requirements

Key responsibilities
Design, execute, and analyze DOE-based formulation experiments to develop and optimize novel LNP formulations
Lead formulation innovation efforts, including lipid selection, composition optimization, and novel process development
Perform LNP screening and characterization, including size, PDI, encapsulation efficiency, stability, and performance metrics

  Lead formulation process scale-up and technology transfer as needed
Collaborate closely with cross-functional teams (biology, analytics, chemistry, and project management) to advance programs
Maintain thorough experimental documentation and clearly communicate results and recommendations to stakeholders
Contribute to troubleshooting formulation challenges and continuously improve experimental workflows
 
Professional experience and qualifications
Scientist, PhD in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biology, or related field with 2+ years relevant experience; OR M.S. with 3+ years; OR B.S. with 5+ years

Associate scientist, M.S. in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biology, or related field with 1+ years relevant experience; OR B.S. with 3+ years

Strong hands-on experience with LNP formulations, including formulation development and optimization, process development and scaling-up
Demonstrated expertise in DOE methodologies and statistical experimental design
Extensive experience with LNP screening and analytical techniques (e.g., DLS, encapsulation assays, stability studies, physicochemical characterization)
Deep understanding of lipid-based delivery systems and formulation science principles
Proven ability to work effectively in a team-oriented, fast-paced environment
Strong problem-solving skills and ability to manage multiple priorities simultaneously
Strong communication skills for presenting data and influencing technical decisions

What We Offer
Opportunity to work at the forefront of LNP formulation innovation
Collaborative, science-driven culture with high impact research
Competitive compensation and benefits package, including health, dental, vision, and life insurance

401(k) with company match