Description
The role
We are seeking a highly motivated Associate, or Sr. Associate, Scientist to work in a fast-paced PD environment applying rigorous scientific principles towards developing a platform process for producing mRNA. This role will play a critical part in developing, optimizing mRNA manufacturing process for lipid nanoparticle drug product development.
Requirements
Key responsibilities
In this capacity, the scientist will produce, purify, and characterize mRNA molecules to enable LNP drug product development
This candidate will use recombinant enzymes to produce and functionalize mRNA, AKTA systems to purify mRNA via affinity and other chromatography methods, TFF to further purify and formulate mRNA, as well as use HPLCs and other biochemical analytical techniques for characterization
An outstanding candidate will be driven by a desire to create, optimize, and define processes with speed in a collaborative environment
Material generation of purified mRNA
Execute and troubleshoot IVT and downstream process development and scaling-up experiments
Manage the flow of samples and data with various downstream users of mRNA
Assist in the design of experiments and interpretation of data
Actively participate and support lab maintenance and continuous improvement initiatives
Maintain accurate and detailed laboratory notebook and documentation
Summarize and present data in group meetings and contribute to group discussions
Author technical reports, study memos, and protocols
Professional experience and qualifications
Scientist, PhD in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biology, or related field with 2+ years relevant experience; OR M.S. with 3+ years; OR B.S. with 5+ years
Associate scientist, M.S. in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biology, or related field with 1+ years relevant experience; OR B.S. with 3+ years
Hands-on experience with the downstream purification of biological molecules (AKTA, chromatography, TFF, viral filtration, etc.)
Experience with molecular cloning, PAGE, and agarose gels
Experience working with, storing, and analyzing purified nucleic acids
Independently motivated with the ability to work in teams
Ability to communicate clearly and concisely through oral presentation and technical writing
Ability to leverage literature, internal and external resources to solve problems and develop new technologies
What We Offer
Opportunity to work at the forefront of nucleic acid science
Collaborative, science-driven culture with high impact research
Competitive compensation and benefits package, including health, dental, vision, and life insurance
401(k) with company match
