Description

Position Overview:
We are seeking a dynamic and experienced individual, with strong multitasking skills to support our ongoing drug discovery and development programs. The person will lead PK/ADME/Clin Pharm for the various CORE oncology programs at various stages.

Key Responsibilities:

-Work with our internal/external teams (CROs) to support various PK/ADME needs for discovery programs, including:

           -Design suitable PK studies for ongoing discovery programs to advance from Hit-to-lead and lead optimization

           -Decipher ADME and metabolism profile to help med chem to design and advance programs at various stages

           -Help to characterize lead candidates with preferred PK/ADME profile based on their chemical and pharmacology properties

            -Use various animal PK/PD data and modeling, to project potential clinical dose range and translational strategy

-Collaborate closely with medicinal chemistry, biology, pharmacology and toxicology for IND enabling studies and regulatory submissions

-Work with our teams, especially our clinical team, for various clinical needs

-Maintain high standards of data quality, documentation, and scientific rigor

Benefits:

-Competitive compensation

-Paid time off (vacation, holidays, and sick leave)

-Flexible work arrangements (hybrid or remote options where applicable)

-Professional development support (e.g., conference attendance, training)

 -401k, Bonus, Equity, Healthcare (Medical, Dental, Vision)

 -Opportunity to work at the forefront of cancer research in a mission-driven startup environment

Requirements

Qualifications:

-PhD in Pharmacokinetics, Pharmaceutical Sciences, Medicinal Chemistry, Analytical Chemistry, or related discipline with 3+ years of relevant industry experience, or MSc with 5+ years of pharmaceutical and biotechnology experience

-Strong foundation in DMPK, ADME, and pharmacokinetics for small-molecule drug discovery, development and clinical

-Experience designing and interpreting in vivo PK/ADME studies, as well drug metabolism profile

-Familiarity with PK/PD modeling tools (e.g., Phoenix, MATLAB, R) is a plus

-Experience working with CROs and managing outsourced studies

-Excellent data analysis, problem-solving, and communication skills

-Comfortable operating in a fast-paced, highly collaborative startup environment

-Self-motivated, adaptable, and eager to take ownership of projects