Description

The Proteomics Group at the Broad Institute of MIT and Harvard is a world-renowned leader in biological mass spectrometry. We are seeking a highly skilled and motivated Senior Research Associate to lead the technical execution of projects in nanoflow hydrogen/deuterium exchange-mass spectrometry (nHDX-MS). This role is designed for a Master’s-level scientist who thrives in the lab, focusing on the end-to-end pipeline of sample handling through data analysis. You will lead collaborative projects at the intersection of cancer biology, epigenetics, and chemical biology under the mentorship of the HDX group leadership.

The successful candidate will drive the technical success of the nHDX platform. Key responsibilities include:

• Manage the full nHDX-MS workflow, including sample preparation, data generation, and initial data interpretation.
• Execute methods to characterize protein-ligand and protein-protein interactions for challenging targets such as membrane proteins and transcription factors. 
• Drive technical development to optimize and advance automated workflows in structural proteomics.
• Assist in advancing analytical capabilities, including the implementation of Electron Transfer Dissociation (ETD) for high spatial resolution. 

 Qualifications:

• A M.Sc. in analytical chemistry, chemical biology, biochemistry or a closely related field.
• A fundamental understanding of molecular biology is highly desired to facilitate sample handling and experimental design.
• Proven hands-on experience in HDX-MS, including sample preparation, data generation and data interpretation.
• Meticulous attention to detail, exceptional organizational skills and a strong track record of scientific excellence.
• Excellent verbal and written communication skills.

Hands-on skills and knowledge in one or more of the following areas will be considered an advantage:

• Expertise in state-of-the-art MS-based proteomics, XL-MS or FPOP
• Proficiency with LEAP or similar liquid handling automation platforms
• Experience with large-scale datasets and proficiency in R or Python 

The Broad Institute is a world-leading non-profit research organization dedicated to realizing the promise of the post-genomic era for human benefit. Located in Cambridge, MA with strong ties to MIT, Harvard, and world class Boston hospitals, the Broad Institute brings together scientists of diverse backgrounds to solve critical problems in biology and medicine in an interdisciplinary manner. The Broad Institute, and the embedded proteomics group (www.broadinstitute.org/proteomics), have an outstanding track-record in training the next generation of research scientists and in developing and applying proteomic technologies critical to address important questions in biology and medicine. We collaborate with top-level researchers throughout the world, and results of these studies and our technology developments are published in top-tier journals. The successful candidate should have both the ability and desire to function in such an open, interdisciplinary, and highly collaborative environment. 

 Interested scientists are encouraged to apply on-line.