Description

At Insmed, every moment and every patient counts - and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you'll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person's contributions to meaningful progress. That commitment has earned us recognition as Science magazine's No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.

For patients, for each other, and for the future of science, we're in. Are you?

About the Role:
We're looking for a highly motivated and experienced bioanalytical scientist to help us expand what's possible for patients with serious diseases. Reporting to the Associate Principal Scientist, the Senior Scientist, Mass Spec will employ their broad knowledge of mass spectrometry for applications ranging from discovery to early-stage development. This individual will also participate in unbiased proteomic biomarker discovery experiments (e.g., LFQ, TMT) in various biological matrices and independently develop targeted assays for protein biomarker quantitation (e.g., LC-MS/MS, MSD, ELISA) to empower drug development.

Additionally, the Senior Scientist will assist in characterizing protein therapeutics by mass spectrometry (e.g., peptide mapping, intact, native) for early phase pipeline advancement. Additional future opportunities to expand existing capabilities include metabolomics, lipidomics, CE-MS, CDMS, and other bioanalytical technologies (e.g., SPR, Jess, BLI) are anticipated.

What You'll Do:

In this role, you'll have the opportunity to Independently develop LC-MS/MS (i.e., Sciex 7500+) assays for protein target quantitation by robust sample preparation (i.e., protein extraction, proteolysis, etc.), assignment of appropriate signature peptide, establishment of analytical figures-of-merit (i.e., linearity, sensitivity, etc.), and method qualification in representative biological matrices. You'll also:

• Perform unbiased proteomic experiments for biomarker discovery by employing proteomic workflows, including appropriate experimental design, reproducible sample preparation, high resolution mass spectrometry data acquisition (Thermo Astral, Eclipse, Excedion), bioinformatic data analysis (i.e., ProteomeDiscoverer, MaxQuant, PEAKS, etc.), and results interpretation.
• Expand upon current sample preparation workflows to include affinity-enrichment and offline fractionation approaches for identification and characterization of low-abundance protein analytes.
• Identify and/or employ complementary bioanalytical techniques (e.g., ELISA, MSD, Western-blot) for better understanding of biological results while working closely with internal SMEs for executing experiments of most value.
• Contribute to the routine analysis of therapeutic protein candidates, including peptide mapping, intact/native protein analysis, data acquisition and reporting to provide analytical support of various research projects.
• Assist the group in lab maintenance and housecleaning, ensuring optimum instrument operation and readiness (i.e., calibration, QA/QC), stocking of reagents/supplies/chemicals, proper waste disposal, sample inventory and CTU management, and strict adherence to safety protocols.

Who You Are:

You have at least a Bachelor's degree in Chemistry, Analytical Chemistry, Biochemistry or a related scientific discipline and a strong focus on proteomic analysis using HRMS and QQQ mass spectrometry platforms. Additionally, you have:

• 5+ years of hands-on experience in applying advanced mass spectrometry techniques for both unbiased protein biomarker discovery and targeted protein quantitation by LC-MS/MS.
• Experience with broad sample preparation methodologies, automation, and instrumentation (Thermo, Sciex).
• Ability to create and perform SRM/MRM experiments on QQQ instruments.
• Experience with LC-MS operation, maintenance, and troubleshooting.
• Strong knowledge of ligand-binding assay development, application, and translation.
• Excellent written and verbal communication skills.
• Strong work ethic, self-motivation, and a collaborative spirit.
• Experience with documentation of scientific data, scientific writing, and presentation of research findings.
• Strict adherence to environmental, health, and safety guidelines.

Nice to have (but not required):

• Strong knowledge of chromatographic separation (e.g., SEC, SCX, HpH RP) highly desired.
• Knowledge of electrophoretic (e.g., CE, SDS-PAGE, IEF) and biophysical interaction (e.g., SPR, BLI) a plus.
• Experience with metabolomic and lipidomic analysis a plus.
• Experience with Top-down and native MS a plus.

Where You'll Work

This role is based out of our Bridgewater, NJ office and requires full-time, in-person presence to support hands-on collaboration, access specialized equipment, and/or operational needs.

Travel Requirements

Minimal travel expected

#LI-MM1

Pay Range:
$127,000.00-165,500.00 Annual

Life at Insmed

At Insmed, you'll find a culture as human as our mission-intentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day, with support for how you work, how you grow, and how you show up for patients, your team, and yourself.

Highlights of our U.S. offerings include:

• Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
• Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration
• 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
• Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
• Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back

Eligibility for specific programs may vary and is subject to the terms and conditions of each plan.

Current Insmed Employees: Please apply via the Jobs Hub in Workday.

Insmed Incorporated is an Equal Opportunity employer. We do not discriminate in hiring on the basis of physical or mental disability, protected veteran status, or any other characteristic protected by federal, state, or local law. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.

Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application or interview process, please contact us by email at TotalRewards@insmed.com and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.