Description

Job Description

Kickstart Your Career at Vertex!
Are you ready to make a real impact? At Vertex, our mission is to tackle serious diseases and to change lives, for the better, for the future. Our aim is to give you the skills, insights, and career guidance to be an important part of that future; to turn your potential into progression. As a Vertex intern or co-op, you'll work on meaningful projects, collaborate with talented teams, and learn from industry leaders. We're passionate about innovation, inclusion, and supporting your growth-inside and outside the lab.

Why Vertex?

• Real Projects: You'll work on assignments that make a real impact, not just busy work.
• Mentorship & Networking: Connect with leaders and peers who want to see you succeed through professional networks, connections, and collaborations that will shape your longer-term career.
• Flexible & Supportive: We offer flexible work options with Flex @ Vertex and prioritize your wellbeing.
• Inclusive Culture: Collaboration and inclusion are embedded in everything we do.
• Career Launchpad: Build skills, explore career paths, and get guidance for your future career.

Ready to apply? Submit your application and let's turn possibilities into reality!

Your Impact
The Vertex In Vitro, DMPK internship program is a multi-week experiential training program for students currently working towards a graduate degree in Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, or a related field of study-- 2+ year of PhD experience required. If you are passionate, collaborative, and growth-minded, an internship at Vertex will help you gain meaningful experience in our DMPK functional areas and serve as a launchpad for your career.

Important Notice Regarding Internship and Co-op Inquiries

At Vertex Pharmaceuticals, we are committed to providing a fair and structured recruitment process for all students interested in internship and co-op opportunities. To ensure consistency and equity, all student applications must go through our Early Talent Acquisition Team.

Due to the high volume of interest, we are unable to respond to individual solicitation. Direct solicitation to Vertex employees- including senior leaders via email will result in removal from the recruiting process.

We appreciate your enthusiasm and interest in Vertex. To be considered for internship or co-op roles, please apply directly through our official application channels. (https://www.vrtx.com/careers/career-growth-and-opportunities/internships/)

Thank you for respecting our process and helping us maintain a fair experience for all candidates.

What you will be doing:
The In Vitro team within the DMPK department uses in vitro permeability assays to screen drug candidates and support the prediction of oral bioavailability via absorption, distribution, metabolism, and excretion (ADME) processes for in vivo-in vitro correlation (IVIVC). The intern position will work with the In Vitro team to method optimize and validate permeability assays to best predict oral bioavailability of small molecules and the expansion to beyond Lipinski's Rule of Five drug candidates.

Responsibilities include:

• In vitro PAMPA assay method optimization and validation with literature compounds at various assay conditions to achieve optimal assay performance, in relation to cell-based in vitro screening assays for best in vivo oral bioavailability prediction
• Exploration of novel in vitro based assays/techniques that mimic physiological state and in vivo formulation compatible to address questions, and for better prediction of bioavailability
• In vitro assay application and expansion to beyond Rule of Five molecules
• Data analysis, correlation, and interpretation compared to published sources
• Discuss and present research progress with In Vitro team, DMPK department, and stakeholders as appropriate

What you will need to succeed:

• Graduate student in pharmaceutical sciences/pharmacology/analytical chemistry (preferably PhD candidate 2+ years of experience minimum)
• Must have experience with operating LC-MS instrumentation
• Significant experience with molecular biology (in vitro) techniques and cell-based assays
• Proficiency with data importing, analysis/processing and scrutiny, visualization, and interpretation using Analyst, Graphpad Prism, SigmaPlot, or related
• History of publications or conference presentation/abstracts
• Strong communication skills with ability to summarize and deliver results at high level
• Demonstrate outstanding determination, persistence, ambition, critical thinking, and problem solving skills
• Knowledge of pharmacokinetics (PK) or pharmacokinetic-pharmacodynamics (PKPD), and statistics is desirable, but not required
• Full-time on-site in Boston, MA capacity required
• Legal authorization to work in the United States, now and in the future. Please note that Vertex does not provide sponsorship for internships or entry level roles within this part of the organization.
• You must be enrolled in an advanced degree program if graduating before August 2026
• You must be available to work full-time, 40 hours per week from May - August 2026

Program Details:

• Full-time, paid internship $35.00 - 50.00 USD/hour
• Program Dates: May - August 2026

At Vertex, we believe that when you feel your best, you can perform at your best. That's why our US benefits and global well-being resources are designed to support you.

• Free 24/7 onsite gym access and free access to group exercise classes

• Subsidized commuter benefits- transit and parking

• Provided meals-free breakfast daily!

• Career development opportunities and events, including C Suite engagement

• Social events-both intern-only and company-wide

• Location-specific perks and extras!

• Recognition of National Intern Day

Equal Opportunities
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Vertex is an E-Verify Employer in the United States. We consider qualified applicants regardless of criminal histories, consistent with legal requirements.

Accessibility & Accommodations
We're focused on attracting, retaining, developing, and advancing our employees. By cultivating a workplace that values diverse experiences, backgrounds, and ideas, we create an environment where every employee can contribute their best. Vertex is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.

Export Control Notice
This position may involve access to technology or data that is subject to U.S. export control laws, including the Export Administration Regulations (EAR). As such, employment is contingent upon the applicant's ability to access export-controlled information in accordance with U.S. law. Due to the nature of the work and regulatory requirements, only individuals who qualify as U.S. persons (citizens, permanent residents, asylees, or refugees) are eligible for this position. For this role, Vertex is unable to sponsor non-U.S. persons to apply for an export control license.

This job posting is for a temporary role with a third-party agency partner that provides services to Vertex. The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer. For any questions or concerns, please contact early_talent@vrtx.com.

Pay Range:
$0 - $0

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:
Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:
1. Hybrid: work remotely up to two days per week; or select
2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Hybrid

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com