Description

Responsibilities:

Mainly responsible for developing bioanalytical quantitation methods for large molecules in biological matrices using LC-MS/MS platform, including triple quadrupole and high resolution MS instrument.
Directly working with method development team head to design the experimental activities to address the bioanalytical challenges of the method, conduct the experiments, summarize the method development results, discussion with the team head of the experimental results and present the results internally and to sponsors.
Simultaneously handle multiple method development projects or method qualification/method validation as required. Coordinate study activities with supervisor and internal team to ensure efficiency and quality of the projects within the timeline.
Coordinate with internal team, like PI and PMs, to deliver the established methods to internal team for method validation and sample analysis within the expected timeline. Provide technical support and troubleshooting in cases the method performance does not meet the expectation.
Keep track of industry trending on the quantitation of large molecules using LC-MS platform. Assess, evaluate and implement new technologies or instruments in the GLP labs to improve the analysis efficiency or data quality.
Set-up, utilize, and maintain complex instrumentation Follow safety precautions

Requirements

Education and Requirements:

Prior working experience working large molecules, such as peptides, Oligos, mAbs, ADCs or sugar, lipids, etc;
Prior working experience in triple quadrupole MS and High Resolution MS instrument; Experience with Sciex QTOF instrument and/or Thermo Orbitrap Exploris HRMS is a plus.
Prior experience developing and validating bio-analytical methods for the quantitation of small molecules and large molecules in biological matrices using LC-MS/MS platform in a GLP lab.
Experience using Sciex Analyst software, OS software, and  Thermo Chromeleon and Watson LIMS is a plus
Proven ability to successfully work in a team environment. Excellent oral and written communication skills. Understanding of experimental design and planning, data collection and summarize the experimental results and presentation skills, and familiar with common data analysis software
Ph.D. in Analytical Chemistry, Biochemistry, Pharmacology or related scientific discipline with 1-2+ years direct experience, OR Master’s degree in same disciplines with 2-4+ years direct experience in large molecules quantitation field using LC-MS/MS platform, OR Bachelor’s degree in same discipline with 5+ years direct experience in large molecules quantitation field using LC-MS/MS platform.