Description

At Gilead our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV treatment and prevention as well as advancements in therapies for viral and inflammatory diseases and certain cancers.

We set and achieve bold ambitions in our fight against the world’s most devastating diseases, united in our commitment to confronting the largest public health challenges of our day and improving the lives of patients for generations to come.

We are seeking a skilled Sr. Associate Scientist to support pharmacokinetic (PK) bioanalysis of large molecules across discovery and early development programs. This individual will play a key role in independently developing, executing, and troubleshooting high throughput bioanalytical assays, while collaborating closely with cross-functional teams to deliver high-quality data that informs critical project decisions. The ideal candidate thrives in a fast-paced, results-driven environment, demonstrates strong scientific ownership, and is eager to expand their impact beyond core bioanalysis into broader drug discovery efforts.

As an Associate Scientist- Biology , at Gilead you will ...
Key Responsibilities:

Design, develop, and execute bioanalytical assays for large molecules  and ADC
Perform ligand-binding assays (LBA) such as ELISA and MSD in different biological matrices to support PK studies
Independently analyze and interpret experimental data, and ensure data quality and integrity
Independently troubleshoot assay performance issues and implement effective solutions
Manage PK sample analysis workflows across multiple studies
Collaborate with DMPK, biology, and project teams
Prepare presentations and written reports
Maintain accurate documentation
Contribute to automation and workflow improvements
Support broader discovery and screening activities
 

Required Qualifications:

BS with 5+ years or MS with 3+ years in Pharmaceutical Science, Biochemistry, Biology or related discipline.
2–3 years of  industry experience in PK bioanalysis, DMPK, or related field
Hands-on experience independently supporting and executing in vivo PK studies for large molecules (e.g., monoclonal antibodies, peptides, biologics)
Expertise in ligand-binding assays (ELISA, MSD, Gyrolab), including assay development, optimization, and troubleshooting
Broad knowledge of PK bioanalytical assays, including ADA
Demonstrated ability to analyze and interpret PK data, including curve fitting (4PL/5PL), QC evaluation, and trend analysis
 Strong understanding of PK/ADME principles for biologics (AUC, clearance, half-life, TMDD, nonlinear PK)
 Working knowledge of antibody-drug conjugates (ADCs) and their bioanalytical challenges
 Proven ability to design experiments and troubleshoot independently
Experience working with biological matrices (serum, plasma, tissue)
 Ability to manage multiple studies and timelines
 Strong communication and presentation skills
Preferred Qualifications:

Experience with LC-MS/MS
Experience with in vitro high throughput screening technologies
Familiarity with HTS (96/384/1536-well formats) and laboratory automation